| Dogwood Health Trust | $800,857,060 | Assistance To Local Nonprofit | Anc Healthcare |
| Adelson Family Foundation | $116,292,396 | General Charitable Purposes | Dr Miriam and Sheldon G Adelson Charitable Trust |
| Monterey Bay Aquarium Research Institute (MBARI) | $45,365,385 | Mbari | David and Lucile Packard Foundation |
| Making Waves Foundation (MWF) | $35,875,000 | Real Estate Expenses | Scully Memorial Foundation |
| Dr Miriam and Sheldon G. Adelson Medical Research Foundation | $29,293,459 | General Charitable Purposes | Dr Miriam and Sheldon G Adelson Charitable Trust |
| Noble Research Institute LLC | $26,000,000 | Operating Support | The Samuel Roberts Noble Foundation |
| Nature Conservation Trust | $25,216,340 | Support for Rwanda Institute of Conservation Agriculture - Rwanda | Howard G Buffett Foundation (HGBF) |
| Blue Cross Blue Shield of Massachusetts Foundation | $25,000,000 | Infrastructure - Rehabilitation for Substance Abuse - Us | Howard G Buffett Foundation (HGBF) |
| Making Waves Foundation (MWF) | $24,200,000 | Real Estate Acquisition | Scully Memorial Foundation |
| Chicago CRED | $23,565,000 | Fund Operations and Programming | The Chicago Community Trust |
| Nature Conservation Trust | $23,393,527 | Support for Rwanda Institute for Conservation Agriculture - Africa | Howard G Buffett Foundation (HGBF) |
| Center To Combat Human Trafficking | $20,110,215 | Community Outreach | ASU Foundation |
| Vogt Family Affiliated Fund of the OKC Community Community Foundation | $20,000,015 | Endowment for Operating Funds of Diversion Hub Included in Maps4 Fbo Justice Involved Individuals | Arnall Family Foundation |
| Heatherington Foundation for Innovation and Education in Health Care | $20,000,000 | General Support | FamilyCare |
| Joy in Blue Foundation | $19,841,197 | Endowment Grant (See Statement 17) | Rathmann Family Foundation |
| Duke Endowment | $19,600,000 | To Support Scaling Plan | Blue Meridian Partners |
| Chick-fil-A Foundation | $18,683,762 | Funding Support for Operations and Grant Making To Organizations That Support Youth Entrepreneurship, Innovative Education and Emerging Leader Development. | A Good Name Foundation |
| Winshape Foundation | $17,392,000 | Funding for Operations | A Good Name Foundation |
| Delta Dental Community Care Foundation | $14,000,000 | | Delta Dental of California |
| Delta Dental Community Care Foundation | $14,000,000 | Enterprise Contribution To DDCCF | Delta Dental of California |
| The Broad | $12,000,000 | Towards Operating Support | Eli and Edythe Broad Foundation |
| Wexner Foundation | $11,000,000 | Support the Development of Jewish Professional and Volunteer Leaders | The Wexner Family Charitable Fund |
| Jacobs Center for Neighborhood Innovation (JCNI) | $10,942,544 | General Operating Support | Jacobs Family Foundation |
| Charles Koch Foundation | $10,000,000 | Support | Zero Zero One |
| Grace and Mercy Foundation | $9,500,000 | General Support | The Fuller Foundation |