Program areas at NAVREF
The function of medin, one of the most common human amyloid proteins that accumulates in the vasculature with aging, remains unknown. This study aism to find the origin and mechanism which activates medin production as a cellular level.
Continuous glucose monitoring (cgm) allows near continuous glucose monitoring throughout the 24-hour cycle, which permits calculation of numerous metrics to better assess both average glucose control as well as within day and between day glucose fluctuations. By combining dexcom cgm data from Veterans from around the country with many years of electronic medical records, there is a unique opportunity to greatly expand the study of cgm benefits to include a variety of acute and chronic complications. We will be able for the first time to compare both short-term complications (e.g., inadequate glucose control, hospitalizations, severe hypoglycemic events, ketoacidosis) and long-term outcomes (e.g., major adverse cardiovascular events, nephropathy, retinopathy) in diabetes patients (1) with and without cgm use; (2) before and after cgm use.
For this bioengineering Research grant, collections of molecular tools and markers unique to the rod microglia variant will be developed, validated, and verified to enable future diagnostic, prognostic, and mechanistic studies of neuroinflammation progression in clinical disease and injury.