Beckman Research Institute of the City of Hope (BRI)

Biomedical Research and disease investigations, including dna synthesis and cell analysis. Beckman Research Institute has pioneered scientific breakthroughs resulting in treatments that have improved the lives of patients worldwide. Numerous life-saving drugs use patented technology developed at Beckman Research Institute. These drugs include synthetic human insulin (humulin) for diabetes, the widely used cancer drugs herceptin, rituxan and avastin, and humira for arthritis. Researchers at Beckman Research Institute undertake fundamental investigations in diabetes progression and treatment, immunology and imaging, interfering rnas and hiv treatment, total synthesis of complex and therapeutic natural products, mechanisms of drug action, neurogenesis, stem cell therapy, dna repair and radiation, and the immunobiology of viral infection. They have achieved major advances in recombinant dna technology, monoclonal antibodies, gene therapy, epigenetics, si-rna technology and cancer immunotherapeutics. A department in Beckman Research Institute is dedicated to understanding and developing treatments based on cancer's interaction with the immune system. Other Research has identified proteins that may play critical roles in immune response and may lead to new treatment strategies. Another major emphasis for the Beckman Research Institute scientists is personalized Research and medicine -- analyzing a patient's unique genetic profile to develop tailored therapies for their specific disease. All of this Research is uniquely supported by onsite manufacturing facilities that can test and produce quantities of cell-based, gene-based and molecular therapies. These facilities further serve as resources for medical and scientific Research centers nationwide. Beckman Research Institute scientists serve as faculty members in City of Hope's irell & manella graduate school of biological sciences. the graduate school's mission is to train students to be outstanding Research scientists in chemical, molecular and cellular biology. the school is accredited by the western association of schools and colleges. Graduates of the program, awarded a doctorate of philosophy in biological sciences, are equipped to address fundamental questions in life sciences and biomedicine for careers in academia, industry and government.