Epigenetic Clock Development Foundation

Internal research program:since inception we have focused on Development of Epigenetic clocks as a key enabling technology for the field. We are a small team of dedicated researchers, and this year hired additional part-time operational, admin, and finance staff, along with a new research associate. We continued to work closely with our scientific advisors, especially on Development of novel testing approaches. The horvath mammalian array, a key enabling technology for translational aging research, was published in nature communications, with additional papers published in 2023 in science and nature aging. Additional papers have been released on dogs in pnas, cats, horses, sheep, marsupials, naked mole rats, and many others. The papers describe the discovery of universal mammalian aging clocks & Epigenetic predictors of maximum lifespan.

External research collaborations: interventional longevity studies we conducted many new interventional studies, for clinical trials and also preclinical studies. This includes studies on plasmapharesis, young plasma treatment, stem cell exosomes, bone marrow transplants, umbilical cord plasma, antiretroviral treatments, and a senolytic gene therapy. We also completed analysis for a >1,000-person longitudinal study of testosterone treatment, analyzing its effects on established clinical & functional aging biomarkers. Mechanisms of aging studies there were many notable mechanistic studies this past year including from the hochedlinger lab on the role of cellular heterogeneity in Epigenetic Clock results, the daley lab on lin28's role in reprogramming, the levin lab on limb regeneration, the gladyshev lab on bone marrow transplants.

Other program services