International Aids Vaccine Initiative (IAVI)

Research and development: through scientific and clinical research in africa, india, europe, and the u.s., Iavi develops vaccines and antibodies in and for the developing world and seeks to accelerate their introduction in low-income countries. Iavi advances scientific discovery and development by fostering unique collaborations among academia, industry, local communities, governments, and funders to explore new and better ways to address public health threats that disproportionately affect people living in poverty. Vaccine and antibody candidates are put through a rigorous process of clinical evaluation among key populations to establish their safety and efficacy, an effort that enables Iavi to strengthen the healthcare infrastructure and scientific capacity of countries where our clinical partners operate. To date, Iavi and its partners have advanced dozens of hiv Vaccine candidates into early stage clinical trials, including a Vaccine that recently yielded promising results and is part of an exciting new approach to hiv Vaccine design. Other notable achievements include the first hiv Vaccine trials in sub-saharan countries, where hiv burden is greatest, and the first trial of an mrna hiv Vaccine candidate in africa. Iavi has conducted more than 50 epidemiological studies and provided voluntary hiv testing, counseling services, and health care referrals to more than 870,000 individuals in africa. Iavi also supports preclinical development and clinical testing of Vaccine candidates for other diseases, including tuberculosis, lassa fever, marburg, ebola suden, and covid-19, as well as antibody candidates for disease prevention and treatment. Iavi conducts trials with the highest scientific and ethical standards to protect the rights, well-being, and dignity of trial volunteers. Iavi has also launched research consortia to address major scientific problems of biomedical product development. A significant portion of the research Iavi supports is conducted in developing countries where the need for infectious disease prevention is greatest. Iavi also supports external researchers by providing technical and scientific expertise to accelerate the development of their own products.